Monoclonal antibody expression systems typically utilise a signal peptide to ensure secretion of the antibody into the cell culture media. Although this reduces the complexity of purification and avoids the need for cell disruption, it does require the use of expensive and/or time-consuming techniques to separate cells from antibody-containing cell culture fluid. In this study, we describe our tests of Sartoclear Dynamics^? Lab V, a novel system for rapid clarification of cell culture media without the need for centrifugation or any other costly equipment.?